Jan van Hest

Adaptive polymer assemblies for biomedical applications

Polymer-based assemblies have much application potential in the biomedical field. We have a special interest in constructing particles with adaptive features, which can change their properties when exposed to external stimuli.  I will first present adaptive particles that can be used in photodynamic therapy (PDT). We have developed particles that, due to their adaptiveness, can improve this treatment. Secondly, I will discuss polymer-stabilized complex coacervates, which can be regarded as artificial cells. The crowdedness of the coacervate mimics the cytoplasm of living cells, whereas the polymer membrane is semi-permeable and allows exchange of molecules between the artificial cell and its environment. This opens opportunities for application in tissue engineering.

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